Gene therapy for hemophilia has been investigated for decades but no breakthroughs were made until Nathwani et al.achieved a significant and sustainable factor IX increase in hemophilia B patients in 2011.About eleven years later, in August 2022, the first hemophilia A gene therapy product was approved by the European Commission and hemophilia trea
Lipids from milk fat globule membranes (MFGMs) and extracellular vesicles (EVs) are considered beneficial for cognitive development and human health.Milk-derived whey concentrates rich in these lipids are therefore used as ingredients in infant formulas to mimic human milk and in medical nutrition products to improve the metabolic fitness of adults
Perturbations in stem cell activity and differentiation can lead to developmental defects and cancer.We use an approach involving a quantitative model of cell-state transitions in vitro to gain insights into how SLUG/SNAI2, a key developmental transcription factor, modulates mammary epithelial Induction Food Warmers stem cell activity and different
Earlier we demonstrated that the adenylyl cyclase (AC) encoded by the MSMEG_4279 gene plays a key role in the resuscitation and growth of dormant Mycobacterium smegmatis and that overexpression of this gene leads to an increase in intracellular cAMP concentration and prevents the transition of M.smegmatis from active growth to dormancy in 141 an ex
Summary: Cellular imaging instrumentation advancements as well as readily available optogenetic and fluorescence sensors have yielded a profound need for fast, accurate, and standardized analysis.Deep-learning architectures have revolutionized the field of biomedical image analysis and have achieved state-of-the-art accuracy.Despite these advanceme